NIH Research Project Grant (Parent R01 Clinical Trial Required) | PA 18 345

Opportunity Information: Apply for PA 18 345

The NIH Research Project Grant (Parent R01 Clinical Trial Required), funding opportunity number PA 18-345, is a National Institutes of Health discretionary grant designed to support a discrete, well-defined research project that fits the scientific expertise of the investigator(s) and aligns with the mission interests of one or more participating NIH Institutes and Centers (ICs). This is a "Parent" R01 announcement, meaning it serves as a broad entry point for investigator-initiated projects across many biomedical, behavioral, clinical, and related research areas, as long as the work clearly maps to an NIH IC's programmatic priorities. The key requirement that sets this particular parent announcement apart is that the application must include at least one clinical trial as part of the proposed research.

Because NIH uses a specific definition of a clinical trial, applicants need to be careful to ensure their study meets that definition and is described accordingly. A central point in the announcement is that some participating ICs will only accept applications through this mechanism when the proposed clinical trial is mechanistic in nature, meaning the trial is intended to understand biological, behavioral, or physiological mechanisms rather than primarily to establish clinical efficacy or effectiveness. The announcement directs applicants to pay close attention to "Related Notices" from specific ICs, since individual NIH components may place additional limits or preferences on what kinds of clinical trials they will accept under this FOA. In practice, that means applicants should confirm early that their trial type, endpoints, and overall aims are a good fit for the IC(s) they plan to target.

Eligibility is broad and includes many types of domestic U.S. organizations and governments, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities/Indian housing authorities. The opportunity is also open to federally recognized Native American tribal governments, as well as Native American tribal organizations that are not federally recognized tribal governments. In addition, both nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (other than small businesses), as well as small businesses, may apply. The announcement also explicitly calls out additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, and eligible federal agencies. Notably, non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions are also listed among eligible applicants, reflecting NIH's openness to high-value clinical research collaborations and projects that may require international or territorial settings.

The sponsoring agency is NIH, and the funding activity category is listed under Education, Environment, and Health, with multiple CFDA numbers associated with NIH programs (including 93.113, 93.172, 93.213, 93.233, 93.273, 93.279, 93.307, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.855, 93.859, and 93.866), which signals that the parent announcement is used across a wide range of NIH institutes and scientific topics. The record shows a creation date of November 3, 2017, and an original closing date of January 7, 2019, as captured in the source information provided. The award ceiling and expected number of awards are not specified in the supplied data, which is common in NIH parent announcements because budgets and award counts vary by institute, fiscal year, application volume, and the availability of appropriated funds.

Overall, this opportunity is best understood as NIH's standard R01 mechanism for investigator-initiated projects where a clinical trial is not optional but required. Applicants are expected to propose a focused project with strong scientific rationale, a design appropriate for a clinical trial under NIH rules, and a clear fit with at least one NIH IC's mission, while also checking institute-specific policies that may narrow what kinds of trials can be submitted through this particular parent announcement.

• The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "NIH Research Project Grant (Parent R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.172, 93.213, 93.233, 93.273, 93.279, 93.307, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.855, 93.859, 93.866.
• This funding opportunity was created on 2017-11-03.
• Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 345

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: